I tend to rotate various proteins with each bag of kibble and case of canned food...I haven't noticed a difference health-wise or even preference-wise in my pups. The biggest difference I can tell between foods is based more on protein/fat content than specific ingredients (higher protein/fat foods from certain brands have given my pups softer stools...so occasionally issues like that but no major problems...I just try to stay with more moderate foods). Our kibble now is Fromm Lamb and Lentil with a chicken-based wet food...and I think we'll do their grain-free salmon variety next. All the proteins we've tried seem to agree equally with the pups! So I basically just try to pick a good quality brand